Interactive plot of the difference of effects of mutations between two conditions.
Use the site zoom bar at the top to zoom in on specific sites. The line plot shows a summary statistic indicating the typical effects of mutations at each site. The heat map shows the effects of individual mutations, with parental amino-acid identities indicated by x, dark gray indicating mutations that fail a slider filter, and light gray indicating non-measured mutations.
You can mouse over points to get details about individual measurements, including measurements in individual selection experiments.
The options at the bottom of the plot let you modify the display, such as by selecting how many different variants a mutation must be seen in to be shown ( minimum times_seen ), the fraction of different pairwise comparisons the mutation was measured in, the maximum standard deviation for the difference among pairwise comparison, or its best effect in any condition.
Analysis by Bernadeta Dadonaite and Jesse Bloom (2023).
See https://github.com/dms-vep/Flu_H5_turkey-Indiana-2022-H5N1_DMS for code/data.